Table 3 Immunohistochemical features of all papillary breast tumors in the current study

From: Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or malignant papillary lesions of the breast: a comparative study of 9 additional cases

Casesa

CK5-6

CK7

P63

Calponin

ER %

PR %

HER2

AR %

TTF1

GCDFP-15

Calretinin

Chromogranin A

Synaptophysin

Ki67 %

IDH1/2-mutant H-score

1

+

+

-

-

60

10

0

80

-

+Focal

+

-

-

2

0

2

+

+

-

-

-

-

0

15

-

+Focal

+

-

-

1

140

3

+

+

-

-

2

-

0

10

-

+Focal

+

-

-

1

200

4

+

+

-

-

-

-

0

-

-

-

+

-

-

6

300

5

+

+

-

-

-

-

0

-

-

+Focal

+

-

-

1

120

6

+

+

-

-

20

20

0

1

-

+Focal

+

-

-

1

230

7

+Focal

+

-

-

-

-

0

-

-

-

+

-

-

1

300

8

-

+

-

-

5

-

0

8

-

+Focal

+

-

-

2

50

9

+

+

-

-

1

1

0

-

-

+Focal

+

-

-

15

0

10

-

+

-

-

100

100

1+

100

-

+Focal

-

-

-

50

0

11

-

+

-

-

90

80

1+

60

-

-

-

-

-

35

0

12

-

+

-

-

90

90

1+

90

-

+Focal

-

-

-

15

0

13

-

+

-

-

100

80

1+

100

-

+

-

-

-

8

0

14

-

+

-

-

90

60

0

80

-

-

-

-

-

40

0

15

-

+

-

-

100

100

0

100

-

-

-

-

-

20

0

16

-

+Focal

-

-

100

100

0

100

-

+

-

-

-

8

0

17

-

+++

-

-

100

95

0

100

-

+

-

-

-

6

0

18

-

+Focal

-

-

100

80

0

80

-

+Focal

-

-

-

5

0

19

-

+Focal

-

-

100

90

0

100

-

-

-

-

-

5

0

20

-

+Focal

-

-

100

100

0

100

-

+

-

-

-

10

0

21

-

+Focal

-

-

100

80

0

100

-

+Focal

-

-

-

10

2

22

+

+

+

+

90

40

0

80

-

+Focal

-

-

-

<1

40

23

+

+

+

+

60

80

0

70

-

+

+Focal

-

-

<1

15

24

+Focal

+

+

+

80

60

0

90

-

+Focal

-

-

-

5

0

25

+

+

+

+

60

60

0

80

-

+

-

-

-

1

0

26

+

+

+

+

60

80

1+

100

-

+Focal

-

-

-

6

0

27

+

+

+

+

80

30

0

90

-

+Focal

+Focal

-

-

2

0

28

-

+

-

-

100

50

0

100

-

+Focal weak

-

-

+Focal

2

0

29

-

+Focal

-

-

100

90

0

100

-

+

-

-

-

8

0

30

-

+Focal

-

-

100

100

0

100

-

+Focal weak

-

-

+Focal

15

0

31

-

+Focal

-

-

100

100

0

100

-

+

-

+Focal

+Focal

5

0

32

-

+Focal

-

-

100

100

0

100

-

+Focal

-

-

-

5

0

33

-

+

-

-

100

100

0

100

-

+

-

+Focal

-

18

0

  1. AR androgen receptor, CK cytokeratin, ER estrogen receptor, GCDFP-15 gross cystic disease fluid protein-15, HER2 human epidermal growth factor receptor 2, IDH2 isocitrate dehydrogenase 2, NA not assesable, PR progesterone receptor, TTF1 thyroid transcription factor 1
  2. aCases: 1 to 9=solid papillary carcinoma with reverse polarity; 10 to 15=invasive micropapillary carcinoma; 16 to 21=encapsulated papillary carcinoma; 22 to 27=intraductal papilloma with usual ductal hyperplasia; 28 to 33=solid papillary carcinoma
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