Table 4 Main histological and immunohistochemical findings of all papillary breast tumors in the current study
SPCRP (n/9) | IMPC (n/6) | EPC (n/6) | IDPUDH (n/6) | SPC (n/6) | |
|---|---|---|---|---|---|
Architecture | Papillary, solid and cystic (9/9) | Micropapillary (6/6) | Papillary (6/6) | Papillary (6/6) | Papillary and solid (6/6) |
Epithelial cell pattern | One population cell organized | One population cell organized | One population cell organized | Two population cell jumbled | One population cell organized |
Nuclear reverse polarity | Present (9/9) | Absent (0/6) | Absent (0/6) | Absent (0/6) | Absent (0/6) |
Myoepithelial cells markers (p63 and calponin) | Absent (9/9) | Absent (0/6) | Absent (0/6) | Present (0/6) | Absent (0/6) |
CK5/6 | Positive (8/9) | Negative (0/6) | Negative (0/6) | Positive (0/6) | Negative (0/6) |
CK7 | Positive (9/9) | Positive (6/6) | Positive or focal (6/6) | Positive (6/6) | Positive or focal (6/6) |
Calretinin | Positive (9/9) | Negative (0/6) | Negative (0/6) | Focal positivity (2/6) | Negative (0/6) |
ER % | Low (<10%) (7/9) | High (≥80%) (6/6) | High (≥80%) (6/6) | High (≥80%) (5/6) | High (≥80%) (6/6) |
Ki67 % | ≤5% (7/9) | ≥20% (4/6) | ≥5 % (6/6) | ≤5% (5/6) | ≥5% (5/6) |
Neuroendocrine markers (chromogranin and synaptophysin) | Negative (0/9) | Negative (0/6) | Negative (0/6) | Negative (0/6) | Positive (4/6) |
IDH1/2 mutant MsMab-1 | Strongly positive (7/9) | Negative (0/6) | Negative (0/6) | Negative or weak (2/6) | Negative (0/6) |
