Fig. 3 | Modern Pathology

Fig. 3

From: Refinement of high-risk endometrial cancer classification using DNA damage response biomarkers: a TransPORTEC initiative

Fig. 3

Poor prognosis endometrial cancer molecular subclasses refinement using DNA Damage and Response bio-markers. Combining an evaluation of Non Homologous End-Joining proficiency (DNA-pk+/FANCD2−) with “TP53 mutated” status and δ-H2AX with “no specific molecular profile” subgroup significantly refined the high-risk endometrial cancer into distinct prognostic subgroups in disease free survival and overall Survival (a graphs and b statistical data). δ-H2AX + Tumors with DNA damage; δ-H2AX− Tumors without DNA damage, NHEJ+ tumors error prone Non Homologous End-Joining proficient, NHEJ− tumors error prone Non Homologous End-Joining not proficient, MSI microsatellite instability, POLE Polymerase Epsilon mutated, P53 TP53 mutated, DF Sease Free Survival, OS Overall Survival. P value *P < 0.05; **P < 0.01 and ***P < 0.001

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