Fig. 3 | Modern Pathology

Fig. 3

From: Advanced septa size quantitation determines the evaluation of histological fibrosis outcome in chronic hepatitis B patients

Fig. 3

Dynamic changes in different collagen structure features quantified by SHG/TPEF-based technology pre- and post treatment. a Heatmap of change of multi-morphological collagen features in total, septal, fibrillar, and portal regions pre- and post treatment. Parameters in general, portal, septal, and perisinusoidal regions were normalized by Lg2 (Mean_78w/Mean_0w). b The change of collagen proportionate area quantified by SHG/TPEF based image analysis of different collagen pattern before and after treatment in different groups. The percentage change was defined as (Value_78w-Value_Baseline)/Value_Baseline, *P < 0.05; **P < 0.001 (Mann–Whitney U-test). SHG: Collagen percentage area quantified by SHG/TPEF. Agg: Aggregated collagen; Dis: Distributed collagen; NoStr: Number of Collagen Strings; NoXlink: Number of Cross-link Strings

Back to article page