Fig. 4

Genomic aberrations in paired metaplastic carcinomas and associated ductal carcinoma in situ. a Summary of pathogenic genomic aberrations in paired invasive and in situ carcinomas. b Representative images of paired ductal carcinoma in situ and invasive metaplastic carcinomas of different histologic subtypes (hematoxylin and eosin). c Representative copy number plots of paired ductal carcinoma in situ and invasive metaplastic carcinoma from tumors with squamous (Sq5) and spindle cell (Sp5) differentiation. Small red arrows highlight shared copy number alterations between in situ and invasive carcinoma, and large black arrows highlight alterations unique to only one of the two components per tumor. DCIS, ductal carcinoma in situ; Inv, invasive; chr, chromosome