Fig. 2 | Modern Pathology

Fig. 2

From: Assessing colorectal cancer mismatch repair status in the modern era: a survey of current practices and re-evaluation of the role of microsatellite instability testing

Fig. 2

A mismatch repair-deficient adenocarcinoma of the sigmoid colon was originally interpreted to show retained mismatch repair protein staining. Non-neoplastic colonic mucosa and lymphoid aggregate (a) show diffuse strong nuclear staining for MLH1 (c) and PMS2 (e). In comparison, tumor cells (b) show positive but reduced and heterogeneous staining of both MLH1 (d) and PMS2 (f)

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