Table 3 Summary of discordant cases between MSI by DNA-PCR and IHC on MMR proteins

From: Assessing colorectal cancer mismatch repair status in the modern era: a survey of current practices and re-evaluation of the role of microsatellite instability testing

 

Original MSI-PCR

Repeat MSI-PCR

Original IHC interpretation

Repeat IHC interpretation

Case #1

MSS

MSS

Loss of MSH6

All 4 markers preserved

Case #2

MSS

MSI-H

Loss of MLH1 and PMS2

Loss of MLH1 and PMS2

Case #3

MSI-H

MSI-H

All 4 markers preserved

Staining for all 4 markers but MLH1 and PMS2 reduced

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