Table 2 Clinical and pathologic characteristics of all study cases

From: Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas

 

Group A

Group B

Group C

Group D

Group E

Total

p value (1)

p value (2)

p value (3)

p value (4)

 

MMRd-LS

MMRd-unexplained

MMRd-sporadic

MMRp-TIL-H

MMRp-consecutive

 

MMRd vs. MMRp

MMRp-TIL-H vs. MMRd

MMRp-TIL-H vs. MMRp-consecutive

MMRd and MMRp-TIL-H vs. MMRp-consecutive

# of patients

23

13

37

17

39

129

    

Sex

 Female

7 (5%)

4 (3%)

24 (19%)

10 (8%)

17 (13%)

62 (48%)

1.0000

0.5912

0.3863

0.5672

 Male

16 (12%)

9 (7%)

13 (10%)

7 (5%)

22 (17%)

67 (52%)

    

Age (yrs, avg ± std)

48.9 ± 14.0

46.1 ± 11.2

68.7 ± 14.4

58.4 ± 11.2

56.0 ± 10.0

57.7 ± 14.6

0.5733

0.9949

0.428

0.3972

Location

Right

16 (12%)

8 (6%)

32 (25%)

13 (10%)

15 (12%)

84 (65%)

<0.0001

0.7390

0.0029

<0.0001

Left

7 (5%)

5 (4%)

5 (4%)

4 (3%)

24 (19%)

45 (35%)

    

Tumor differentiation

WD to MD

14 (11%)

7 (5%)

24 (19%)

15 (12%)

36 (28%)

96 (74%)

0.0002

0.0459

0.6339

0.0019

PD

9 (7%)

6 (5%)

13 (10%)

2 (2%)

3 (2%)

33 (26%)

    

Histological patterns (dominant pattern)

   Mucinous

3 (2%)

3 (2%)

2 (2%)

1 (1%)

1 (1%)

10 (8%)

0.1841

1.000

0.5188

0.2805

Medullary

1 (1%)

2 (2%)

9 (7%)

0

0

0

0.0011

0.1128

–

0.0175

Perineural invasion

Absent

21 (16%)

11 (9%)

33 (26%)

16 (12%)

26 (20%)

107 (83%)

0.0570

1.0000

0.0428

0.0021

Present

2 (2%)

2 (2%)

4 (3%)

1 (1%)

13 (10%)

22 (17%)

    

Lymphovascular invasion

Absent

15 (12%)

9 (7%)

19 (15%)

10 (8%)

16 (12%)

63 (53%)

0.1067

1.0000

0.2553

0.0835

Present

8 (6%)

4 (3%)

18 (14%)

7 (5%)

23 (18%)

60 (47%)

    

Lymphocytic infiltrate

TILs/HPF (mean ± std)

23.91 ± 22.62

27.00 ± 23.89

55.86 ± 80.76

38.06 ± 24.79

1.82 ± 1.47

28.57 ± 50.02

0.0015

0.8646

<0.0001

<0.0001

Peritumoral lymphoid aggregates (mean ± std)

10.5 ± 11.6

6.9 ± 6.1

6.4 ± 6.5

4.6 ± 4.8

3.2 ± 5.2

5.9 ± 7.4

0.0017

0.1514

0.3315

0.0053

T stage

T1/2

6 (5%)

2 (2%)

6 (5%)

8 (6%)

9 (7%)

31 (24%)

0.2105

0.0264

0.1133

1.0000

T3/4

17 (13%)

11 (9%)

31 (24%)

9 (7%)

30 (23%)

98 (76%)

    

N stage

N0

15 (12%)

7 (5%)

27 (21%)

13 (10%)

23 (18%)

85 (66%)

0.7063

0.5679

0.2423

0.3146

N1/2

8 (6%)

6 (5%)

10 (8%)

4 (3%)

16 (12%)

44 (34%)

    

M stage

M0

22 (17%)

12 (9%)

34 (26%)

17 (13%)

37 (29%)

122 (95%)

0.4672

0.5790

1.000

1.0000

M1

1 (1%)

1 (1%)

3 (2%)

0

2 (2%)

7 (5%)

    
  1. MMRd mismatch repair deficient, MMRp mismatch repair proficient, TIL-H tumor infiltrating lymphocytes high, WD well differentiated, MD moderately differentiated, PD poorly differentiated, HPF high power field. Bold values indicate statistical significance
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