Fig. 3
Epithelioid hemangioendothelioma of the liver. (a) Core needle biopsy of a liver mass from a 60-year-old woman who presented with multiple hepatic nodules. The liver parenchyma is infiltrated by a cellular neoplasm with hyalinized stroma. (b) Much of the biopsy consisted of nearly normal liver parenchyma with a subtle hypercellularity. (c) The hepatic sinusoids contain scattered hyperchromatic and multinucleated cells. (d) Immunohistochemistry for CAMTA1 shows nuclear staining in the atypical cells within the sinusoids. (e) Other areas of the biopsy show more typical cytoarchitectural features of epithelioid hemangioendothelioma, with cords of epithelioid cells containing occasional cytoplasmic vacuoles, embedded in a collagenous stroma. (f) CAMTA1 highlights the cord-like architecture. CAMTA1 expression correlates with the pathognomonic WWTR1-CAMTA1 gene fusion
