Fig. 2

Comparison of the novel analytical and traditional arithmetic average methods. a Novel analytical and traditional average methods for CpGs 75–78. The respective optimal cut-off values are calculated in Table 2. The cut-off for the novel model was determined by the positive (Pos) and negative (Neg) numbers of selected CpGs. b The best cut-off for the novel analytical model was calculated by the receiver operating characteristic curve analysis. AUC, area under the curve