Table 2 Cox regression analysis of biochemical recurrence-free survival in ISUP grade 2 prostate cancer patients without lymph node metastasis at time of operation (n = 408)

From: Large cribriform growth pattern identifies ISUP grade 2 prostate cancer at high risk for recurrence and metastasis

 

Univariate analysis

Multivariable analysis

 

HR

95% CI

P value

HR

95% CI

P value

Age

0.99

0.96–1.03

0.56

0.99

0.95–1.03

0.57

PSA

1.02

1.01–1.04

<0.001

1.01

0.99–1.02

0.34

pT-stage

T2

T3a

2.00

1.27–3.14

0.003

1.64

1.02–2.63

0.04

T3b

4.42

2.24–8.72

<0.001

3.00

1.42–6.34

0.004

Positive surgical margin

3.24

2.11–4.97

<0.001

3.28

2.06–5.23

<0.001

Percentage Gleason 4

1.26

0.82–1.93

0.29

0.94

0.59–1.51

0.80

Tertiary Gleason 5

1.29

0.66–2.50

0.46

0.95

0.44–2.06

0.90

IDC-P

2.13

1.36–3.36

0.001

1.32

0.77–2.25

0.31

Invasive cribriform

Small

1.50

0.95–2.37

0.09

1.07

0.65–1.75

0.80

Large

3.98

2.10–7.57

<0.001

4.36

2.08–9.17

<0.001

  1. HR hazard ratio; CI confidence interval.
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