Table 2 Association between nuclear 53BP1 expression and pathological classification in nonalcoholic fatty liver disease patients
Fibrosis | n | Abnormal 53BP1 foci (%) | Large 53BP1 foci (%) |
|---|---|---|---|
0 | 8 | 17.1 ± 10.2 | 1.5 ± 1.6 |
1 | 15 | 22.8 ± 18.9 | 5.2 ± 4.1 |
2 | 4 | 18.0 ± 10.7 | 7.5 ± 6.5 |
3 | 10 | 23.3 ± 15.3 | 6.2 ± 3.9 |
4 | 5 | 26.4 ± 16.2 | 7.6 ± 3.2 |
n.s. | p < 0.01 | ||
Portal inflammation | n | Abnormal 53BP1 foci (%) | Large 53BP1 foci (%) |
0 | 10 | 12.6 ± 8.6 | 2.5 ± 2.9 |
1 | 26 | 22.0 ± 16.5 | 6.1 ± 4.7 |
2 | 6 | 37.8 ± 9.5 | 6.4 ± 2.8 |
p < 0.05 | p < 0.05 | ||
Steatosis | n | Abnormal 53BP1 foci (%) | Large 53BP1 foci (%) |
1 | 14 | 22.2 ± 12.9 | 3.4 ± 3.7 |
2 | 14 | 26.5 ± 18.4 | 5.3 ± 3.1 |
3 | 14 | 16.7 ± 14.4 | 6.9 ± 5.3 |
n.s. | p < 0.05 | ||
Hepatocyte ballooning | n | Abnormal 53BP1 foci (%) | Large 53BP1 foci (%) |
0 | 5 | 17.5 ± 13.5 | 1.8 ± 1.7 |
1 | 20 | 23.8 ± 16.3 | 6.4 ± 5.3 |
2 | 17 | 20.7 ± 15.7 | 4.8 ± 2.9 |
n.s. | n.s. | ||
Lobular inflammation | n | Abnormal 53BP1 foci (%) | Large 53BP1 foci (%) |
0 | 5 | 9.3 ± 5.6 | 2.1 ± 1.7 |
1 | 28 | 22.7 ± 17.0 | 5.8 ± 4.6 |
2 | 9 | 25.9 ± 12.7 | 5.0 ± 4.0 |
n.s. | n.s. | ||
Nonalcoholic fatty liver disease activity score total | n | Abnormal 53BP1 foci (%) | Large 53BP1 foci (%) |
1 | 3 | 11.2 ± 5.5 | 1.3 ± 0.92 |
2 | 1 | 24.4 ± 0 | 5.6 ± 0 |
3 | 7 | 25.8 ± 13.6 | 4.9 ± 4.3 |
4 | 10 | 25.3 ± 15.3 | 4.8 ± 3.4 |
5 | 10 | 22.8 ± 21.8 | 7.4 ± 5.5 |
6 | 6 | 17.6 ± 10.5 | 5.8 ± 3.7 |
7 | 4 | 19.2 ± 12.3 | 5.5 ± 3.8 |
8 | 1 | 21.8 ± 0 | 2.7 ± 0 |
n.s. | n.s. |
