Fig. 2 | Modern Pathology

Fig. 2

From: JAK2/PD-L1/PD-L2 (9p24.1) amplifications in renal cell carcinomas with sarcomatoid transformation: implications for clinical management

Fig. 2

Histopathology, fluorescence in situ hybridization and immunohistochemistry (Case 1 & 4). Representative H&E-stained images of 9p24.1-amplified sarcomatoid renal cell carcinomas (a Case 4, 2.7-fold amplification by MSK-IMPACT, ×400 magnification; d Case 1, 3.5-fold amplification by MSK-IMPACT, ×200 magnification), corresponding fluorescence in situ hybridization (b Red: PD-L1, Green: PD-L2, Aqua: Centromere; e Orange: JAK2, Green: INSL6, Red: Centromere) and immunohistochemistry (c PD-L1, ×400 magnification; f phospho-STAT3, ×200 magnification) have been depicted. MSK-IMPACT, Memorial Sloan Kettering Cancer Center Integrated Mutation Profiling of Actionable Cancer Targets

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