Fig. 3 | Modern Pathology

Fig. 3

From: Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss

Fig. 3

H&E (left) and H3K27me3 (middle) and H3K27me2 (right) immunohistochemical staining for representative cases of tumors characterized by loss of H3K27me3. a Malignant peripheral nerve sheath tumor, b K27M glioma, c PF-A Ependymoma, and d Merkel cell carcinoma. Of these tumors, only malignant peripheral nerve sheath tumor exhibits loss of nuclear H3K27me2 staining within tumor cells

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