Fig. 3 | Modern Pathology

Fig. 3

From: Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma

Fig. 3

Immunophenotypes of MCPyV-negative and -positive Merkel cell carcinoma cases (bar = 100 µm): Immunohistochemical investigation of CD99 (a), cytokeratins 7 (b), 8 (c), 18 (d) and 20 (e), EMA (f), p53 (g) and TTF-1 (h) revealed several distinctive features between the two groups: MCPyV-positive status was associated with cytokeratins 8, 18 and 20 and CD99 dot-like expression pattern as well as high EMA expression, whereas MCPyV-negative cases frequently displayed expression of cytokeratin 7 and TTF-1 and abnormal p53 expression. MCC: Merkel cell carcinoma

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