Fig. 1 | Modern Pathology

Fig. 1

From: PD-L1 expression is associated with ALK positivity and STAT3 activation, but not outcome in patients with systemic anaplastic large cell lymphoma

Fig. 1

An ALK+ anaplastic large cell lymphoma case with strong PD-L1 expression. The lymphoma cells were large, with pleomorphic, often horseshoe- or kidney-shaped nuclei and abundant cytoplasm (a, hematoxylin and eosin stain, ×400). The lymphoma cells showed uniform, strong CD30 positivity on the cell membrane and in the Golgi region (b, immunohistochemistry, ×400), loss of CD3 expression (c, immunohistochemistry, ×400), nuclear and cytoplasmic staining for ALK (d, immunohistochemistry, ×400), and granzyme B positivity (e, immunohistochemistry, ×400). The lymphoma cells were positive for PD-L1, mainly membranous staining, with a small subset of cells showing Golgi staining pattern (f, immunohistochemistry, ×400)

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