Table 4 Multivariate Cox proportional hazards model on overall survival using raw PD-L1 scores in MPM (n = 302)

From: V-domain Ig-containing suppressor of T-cell activation (VISTA), a potentially targetable immune checkpoint molecule, is highly expressed in epithelioid malignant pleural mesothelioma

 

Hazard ratio

95% CI of HR

p-value

Concordance index

PD-L1 raw score (10% increment)

1.1

1.0 to 1.1

0.002

0.654

Histology

   

  Biphasic vs. epithelioid

1.8

1.2 to 2.5

0.002

  Sarcomatoid vs. epithelioid

1.9

1.2 to 3.0

0.007

Stage

   

  2 vs. 1

2.1

1.1 to 4.2

0.035

  3 vs. 1

3.2

1.6 to 6.3

<0.001

  4 vs. 1

3.6

1.7 to 7.3

<0.001

Age

1.0

1.0 to 1.0

0.415

Gender, male vs. female

1.5

1.2 to 2.0

0.002

  1. CI confidence interval, HR hazard ratio, MPM malignant pleural mesothelioma, n number, PD-L1 programmed cell death-ligand 1, vs. versus
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