Table 10 Salient clinical, histologic, and immunohistochemical features of digital papillary adenocarcinoma
From: Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors
Digital papillary adenocarcinoma | ||
|---|---|---|
Clinical features | Histologic features | Immunohistochemistry |
Nodules (2 cm) Hands and feet Wide age distribution M > F Potential for disseminated disease and mortality | Nodular, circumscribed, unencapsulated Rarely infiltrative Dermal based, ±superficial subcutis Solid and cystic with tubular and papillary differentiation Morphologically low- to high-grade without impact on behavior Preserved second myoepithelial cell layer | Positive AE1/3 S100 Myoepithelial cell layer: SMA Calponin P63 P40 |
