Table 8 Salient clinical, histologic, and immunohistochemical features of adenoid cystic carcinoma
From: Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors
Adenoid cystic carcinoma | ||
|---|---|---|
Clinical features | Histologic features | Immunohistochemistry |
Slowly growing nodules and plaques (3 cm) Head and neck > trunk and extremities Middle-aged to elderly adults Locally destructive growth Local recurrence Rare metastases and mortality | Diffusely infiltrative growth in dermis with invasion of subcutis Basaloid nests and islands of varying shapes and sizes Mucinous pseudocysts with cribriform architecture Focal duct differentiation and tubular growth Solid, cribriform, and cystic patterns Mild to moderate cytologic atypia Low mitotic activity | Positive AE1/3 S100 SOX10 SMA CD117 MYB |
