Table 2 Based on the histopathological evaluation, all patients (n = 51) were divided into two groups: chronic sclerosing sialadenitis or non-sclerosing chronic sialadenitis. This table summarizes the histopathological and immunohistological findings in chronic sclerosing sialadenitis and non-sclerosing chronic sialadenitis

From: Sclerosing sialadenitis of the submandibular gland is rarely an immunoglobulin G4-related disease in the Finnish population

 

Chronic sclerosing sialadenitis

Non-sclerosing chronic sialadenitis

n = 34

%

n = 17

%

H&E-staining

 Associated sialolithiasis

11

32

8

47

 Dense lymphoplasmacytic infiltrate

29

85

11

65

 Germinal centers with lymphoid follicles

29

85

9

53

 Fibrosis: storiform

20

58

6

35

 Fibrosis: dense

28

82

15

88

 Eosinophilic infiltrate

1

3

1

6

IgG4-staining

 ≥70 IgG4 + plasma cells/HPF

8

24

4

24

 Additional IgGa and CD31b staining

n = 8

%

n = 4

%

 IgG4/IgG-plasma cell ratio ≥40%

3

38

3

75

 Obliterative phlebitis

1

13

2

50

  1. H&E hematoxylin and eosin, HPF high-power field
  2. aIgG-staining was performed only in the 12 specimens showing IgG4-positive plasma cell infiltrates >70 IgG4-positive plasma cells/HPF
  3. bCD31-staining was performed only in the 12 specimens showing IgG4-positive plasma cell infiltrates >70 IgG4-positive plasma cells/HPF