Table 3 Summary of histological, immunohistochemical, and clinical features in patients (n = 12) with ≥70 IgG4-positive plasma cells/HPF (40×) in their tissue specimens. Two patients (non-sclerosing chronic sialadenitis nos. 3 and 4) fulfilled the the criteria for immunoglobulin G4-related disease

Case no.	IgG4 + plasma cells/HPF	IgG4/IgG-plasma cell ratio, %	Associated sialolith	Germinal centers with lymphoid follicles	Lympho- plasmacytic infiltrate	Fibrosis: storiform	Fibrosis: dense	Lesion involves whole gland	Obliterative phlebitis	Eosinophilic infiltrate	Age/sex	Duration of symptoms (mths or yrs)	Intermittent symptoms	History of asthma	History of allergies	Confirmed IgG4-related disease	Other autoimmune disease
*Chronic sclerosing sialadenitis*
1	73	27	No	Yes	Moderate	No	Yes	Yes	No	No	79/F	2 mths	no	no	yes	no	no
2	92	94	No	Yes	Moderate	No	Yes	Yes	No	No	60/M	10 mths	no	no	no	no	no
3	75	55	Yes	Yes	Strong	No	Yes	Yes	No	No	29/M	10 yrs	yes	yes	no	no	no
4	70	59	Yes	Yes	Strong	No	Yes	Yes	Yes	No	61/M	3 yrs	yes	no	no	no	no
5	115	38	Yes	Yes	Moderate	Yes	Yes	Yes	No	No	61/F	2 mths	no	yes	no	no	no
6	76	32	Yes	Yes	Strong	no	No	yes	No	No	62/F	3 mths	yes	no	no	no	no
7	114	38	Yes	Yes	Strong	No	Yes	Yes	No	No	58/F	1 mth	no	no	no	no	yes
8	70	27	Yes	No	Weak	No	Yes	Yes	No	No	47/M	1 yr	yes	no	no	no	no
*Non-sclerosing chronic sialadenitis*
1	136	54	Yes	Yes	Moderate	No	Yes	Yes	No	No	75/F	10 yrs	Yes	No	No	No	No
2	105	35	Yes	Yes	Strong	Yes	Yes	Yes	Yes	No	63/F	10 yrs	Yes	No	No	No	Yes
3	125	71	No	Yes	Strong	Yes	Yes	Yes	No	No	25/M	1 yr	Yes	Yes	No	Yes	No
4	188	63	No	Yes	Strong	Yes	No	Yes	Yes	Yes	63/M	1 yr	No	No	No	Yes	No

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