Table 1 Association of atrial amyloidosis with demographics and clinical characteristics

From: Amyloidosis in surgically resected atrial appendages: a study of 345 consecutive cases with clinical implications

 

Total (n = 345)

Amyloid (−) (n = 185)

Amyloid (+) (n = 160)

p value

Odd ratio (95%CI; p value)

Demographic features

Age at surgery, years

   

<0.0001a

 

 Mean ± SD

69 ± 12

65 ± 13

74 ± 9

  

 Range

26–92

26–89

31–92

  

Sex

   

0.0161b

 

 Female

137 (40%)

59 (43%)

78 (57%)

  

 Male

208 (60%)

126 (61%)

82 (39%)

  

BSA, m2

2.04 ± 0.29

2.085 ± 0.29

1.98 ± 0.28

0.4880c

 

BMI, kg/m2

29.78 ± 6.39

30.18 ± 6.53

29.33 ± 6.21

0.3251c

 

Clinical features

Stroke / TIA

   

0.0181

2.03 (1.1–3.7; 0.0196)d

 Yes

54 (16%)

21 (39%)

33 (61%)

  

 No

291 (84%)

164 (56%)

127 (44%)

  

Systemic hypertension

   

0.0291

1.74 (1.1–2.9; 0.0300)

 Yes

257 (74%)

129 (50%)

128 (50%)

  

 No

88 (26%)

56 (64%)

32 (36%)

  

Coronary artery disease

   

0.1036

 

 Yes

253 (73%)

129 (51%)

124 (49%)

  

 No

92 (27%)

56 (61%)

36 (39%)

  
  1. BSA body surface area, BMI body mass index, TIA transient ischemic attack
  2. Data are mean ± standard deviation or number (percentage)
  3. aMultivariate model adjusted for sex
  4. bMultivariate model adjusted for age at surgery
  5. cMultivariate model adjusted for age at surgery and sex
  6. dWhen adjusted for age at surgery using logistic regression analysis, correlation between amyloidosis and stroke/TIA was still significant (Odd ratio, 2.7; 95% confidence interval, 1.5–5; p, 0.0013)
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