Table 1 Histologic features of secretory carcinoma.
From: Characterization of novel genetic alterations in salivary gland secretory carcinoma
Variables | Secretory carcinoma (N = 22) | Acinic cell carcinoma (N = 36) |
|---|---|---|
Gross appearance | ||
Single-round | 15 (68%) | 16 (44%) |
Multi-lobulated | 7 (32%) | 20 (56%) |
Tumor border | ||
Pushing | 14 (64%) | 25 (69%) |
Infiltrative | 8 (36%) | 11 (31%) |
Dominant growth pattern | ||
Solid | 0 (0%) | 29 (81%) |
Microcystic | 6 (27%) | 7 (19%) |
Papillary cystic | 14 (64%) | 0 (0%) |
Cribrifrom | 2 (9%) | 0 (0%) |
Tumor stroma | ||
Sclerosis | 22 (100%) | 31 (86%) |
Lymphocyte-rich | 0 (0%) | 5 (14%) |
Zymogen granule | ||
Prominent | 0 (0%) | 30 (83%) |
Focally present | 0 (0%) | 6 (17%) |
Absent | 22 (100%) | 0 (0%) |
Lymphovascular invasion | 0 (0%) | 2 (6%) |
Perineural invasion | 2 (9%) | 4 (11%) |
Immunohistochemistry | ||
DOG1 expression | 2 (9%; focal) | 36 (100%; 36 diffuse) |
S100 expression | 22 (100%; 21 diffuse and 1 focal) | 0 (0%) |
Mammaglobin expression | 20 (91%; 17 diffuse and 3 focal) | 0 (0%) |
P63 expression | 0 (0%) | 0 (0%) |
ETV6 gene | ||
Translocated | 19 (86%) | Not done |
Not translocated | 3 (14%) | |
