Table 5 Multivariate outcome analysis by cox regression, overall survival

From: CD274 (PD-L1), CDKN2A (p16), TP53, and EGFR immunohistochemical profile in primary, recurrent and metastatic vulvar cancer

 

HPV DNA negative

HPV DNA positive

p value

Overall survivala

 

HR (95%Cl)

p value

CDKN2A

 Negative (n = 72)

55 (76%)

17 (24%)

0.003

0.30 (0.073–1.263)

0.10

 Positive (n = 12)

3 (25%)

9 (75%)

TP53

 Negative (n = 56)

37 (66%)

19 (34%)

0.06

1.38 (0.75–2.52)

0.30

 Positive (n = 28)

21 (75%)

7 (25%)

EGFR

 Negative (n = 73)

49 (66%)

24 (33%)

0.54

1.03 (0.49–2.16)

0.94

 Positive (n = 11)

9 (85%)

2 (15%)

CD274

 Negative (n = 62)

41 (66%)

21 (34%)

0.43

1.15 (0.57–2.32)

0.70

 Positive (n = 21)

16 (76%)

5 (24%)

  1. aAdjusted to the confounding factors: age and stage
  2. Bold values indicate statistical significance p-values