Table 1 Clinicopathologic features of cases included in study.

From: A novel group of HPV-related adenocarcinomas of the lower anogenital tract (vagina, vulva, and anorectum) in women and men resembling HPV-related endocervical adenocarcinomas

Case #

Age

Gender

Clinical presentation

Anatomic location of tumor

Procedure

Imaging study findings

Tumor size (cm)

Therapy

Disease status/follow-up (months)

1

41

F

Mass

Vagina

Excision

NA

5.8

XRT

Alive, no evidence of disease (91)

1R

47

 

Recurrences at 36 and 72 months

Bulk of tumor in vagina with microscopic involvement of cervix

Total hysterectomy, bilateral salpingo-oophorectomy, vaginectomy, and exenteration

PET at 72 months: uptake in posterior and lateral vaginal walls

2.5

Chemo and brachytherapy (36 months), resection (72 months)

2

67

F

Painless bleeding

Anorectum

Excision

No disease elsewhere

3.5

Abdominoperineal resection (no residual tumor),

Alive, no evidence of disease (6)

3

69

M

Asymptomatic, screening colonoscopy

Anorectum

Mucosal resection

No disease elsewhere

8.4

Chemoradiation therapy

No evidence of disease (36)

4

43

F

Mass

Vulva

Biopsy

NA

3

NA

NA

5

64

M

NA

Anorectum

Excision

No disease elsewhere

5

NA

NA

6

38

F

Nodule

Vulva

Excision

NA

NA

Radiotherapy

Local recurrence (72)

7

38

F

NA

Vagina

NA

No disease elsewhere

NA

NA

Alive, no evidence of disease (56)

8

41

F

NA

Vagina

Excision

NA

2

NA

NA

9

51

F

Mass

Vagina

Biopsy

NA

NA

NA

NA

  1. R recurrences, NA not available