Table 2 Ancillary immunohistochemical and HPV testing results.

From: A novel group of HPV-related adenocarcinomas of the lower anogenital tract (vagina, vulva, and anorectum) in women and men resembling HPV-related endocervical adenocarcinomas

Case #

Anatomic site

p16

HPV ISH

HPV PCR

CK7

CK20

CDX2

Pax8

ER

PR

1

Vagina

+ (Diffuse)

+ (HPV 31)

NP

NP

NP

NP

1R

Vagina

NP

NP

NP

NP

NP

NP

NP

NP

NP

2

Anorectum

+ (Diffuse)

+

NP

+

+ (Focal)

3

Anorectum

+ (Diffuse)

NP

+ (HPV 18)

+

+ (Focal)

NP

NP

4

Vulva

+ (Diffuse)

+ (HPV 16)

NP

+

+ (Focal)

+ (Focal)

NP

5

Anorectum

+ (Diffuse)

NP

NP

NP

NP

NP

NP

NP

NP

6

Vulva

+ (Diffuse)

NP

NP

+

NP

NP

NP

NP

NP

7

Vagina

+ (Diffuse)

NP

+ (HPV 16)

+

+ (Focal)

+

NP

8

Vagina

+ (Diffuse)

NP

+ (HPV 18)

+

+ (Focal)

+

NP

9

Vagina

+ (Diffuse)

NP

+ (Cocktail)

+

+ (Focal)

NP

NP

NP

  1. HPV human papillomavirus, ISH in situ hybridization, PCR polymerase chain reaction, NP not performed