Table 1 Clinicopathologic features of sequenced pleomorphic LCIS and florid LCIS.

From: Genetic analysis of pleomorphic and florid lobular carcinoma in situ variants: frequent ERBB2/ERBB3 alterations and clonal relationship to classic lobular carcinoma in situ and invasive lobular carcinoma

Case #

Age

LCIS variant

Size (cm)

LCIS variant

Nec

Classic LCIS

ILC pattern

SBR grade

Size (cm)

ILC

Initial surgery

Stage

Follow-up (mo)

ER

PR

HER2

ER

PR

HER2

P1

55

PLCISa

3.3

Pos

Neg

Neg

N

Y

Pleomorphic

2

7.7

Pos

Neg

Neg

M

pT3N0(i+)(sn)

ANED (41)

P2

53

PLCISb

3.3

Neg

Neg

Neg

Y

N

Pleomorphicb

3

0.6

Neg

Neg

Neg

LE

pT1b(m)N0(sn)

ANED (46)

P3

72

PLCISc

1.8

Pos

Pos

Pos

Y

Y

Pleomorphic

2

0.6

Pos

Pos

Pos

LE

pT1bN0(sn)

ANED (7)

P4

62

PLCIS

3.5

Pos

Pos

Neg

Y

Y

Classic

2

4

Pos

Pos

Neg

LE

pT2N0(sn)

ANED (36)

P5

60

PLCISa,c

4.5

Pos

Neg

Neg

Y

Y

Pleomorphic and alveolar

2

4.5

Pos

Neg

Neg

LE

pT2N3a

DOD (20)

P6

57

PLCISa

10

Posd

Neg

Neg

Y

Y

Pleomorphic

2

0.6

Neg

Neg

Neg

M

pT1bN0(sn)

ANED (126)

P7

73

PLCISa

2.4

Pos

Pos

Pos

Y

Y

Pleomorphic

2

0.7

Pos

Pos

Pos

LE

pT1bN0(sn)

ANED (10)

pP1

74

PLCISc

3.2

Pos

Neg

Neg

Y

Y

–

–

–

–

LE

–

ANED (106)

pP2

81

Apocrine PLCIS

2.7

Neg

Neg

Neg

N

N

–

–

–

–

LE

–

ANED (40)

pP3

61

Apocrine PLCIS

4.3

Neg

Neg

Neg

N

Y

–

–

–

–

M

–

ANED (35)

F1

40

FLCIS

2.2

Pos

Pos

Neg

Y

Y

Classic and alveolar

2

4.4

Pos

Pos

Neg

M

pT2N0(sn)

ANED (67)

F2

49

FLCIS

8.2

Pos

Pos

Neg

Y

Y

Classic and alveolar

2

9.1

Pos

Pos

Neg

M

pT3N0(sn)

ANED (48)

F3

61

FLCISe

3

Pos

Pos

Neg

N

Y

Pleomorphic and solid

3

5

Pos

Pos

Neg

M

pT2N1mi(sn)

ANED (61)

F4

68

FLCIS

4.8, 2.1

Pos

Pos

Neg

Y

Y

Classic

2

0.3

Pos

Neg

Neg

LE

pT1aN0(sn)

ANED (52)

pF1

51

FLCIS

0.9

Pos

Pos

Neg

N

Y

–

–

–

–

M

–

ANED (20)

pF2

55

FLCIS

0.4f

Pos

Neg

Neg

N

Y

–

–

–

–

–

–

ANED (75)

  1. ANED alive, no evidence of disease, DOD died of disease, FLCIS florid LCIS, ILC invasive lobular carcinoma, LCIS lobular carcinoma in situ, LE local excision, M mastectomy, NA not available, Nec necrosis, PLCIS pleomorphic LCIS, SBR modified Scarff-Bloom Richardson
  2. aDuctal carcinoma in situ also present
  3. bInvasive ductal carcinoma (0.2 cm, SBR grade 2, ER+/PR+/HER2−) and high-grade ductal carcinoma in situ (ER−/PR−) also present
  4. cFLCIS also present
  5. dWeakly ER positive
  6. ePLCIS also present
  7. fSize on core biopsy