Table 1 SHG parameters definition.

From: Prognostic value of desmoplastic stroma in intrahepatic cholangiocarcinoma

Analysis type

Output

Acronym

definition

Collagen intensity

Collagen area ratio

CAR

Relative amount of collagen compared to the total region of interest

 

Saturated collagen area ratio

SCAR

Area of collagen that has pixels equal to 255 only

 

Unsaturated collagen area ratio

UCAR

Area of collagen minus the area of collagen that has saturated pixels

 

Collagen area ratio in tissue

CART

Relative amount of collagen compared to the total tissue area.

 

Saturated collagen area ratio in tissue

SCART

Relative amount of saturated collagen compared to the total tissue area.

 

Unsaturated Collagen Area Ratio per Tissue

UCART

Relative amount of unsaturated collagen compared to the total tissue area

 

Collagen fiber density

CFD

Measure of how closely packed collagen fibers are to each other (defined by the sum of all collagen pixel intensities divided by the collagen area)

 

Unsaturated collagen fiber density

UCFD

Measure of how closely packed collagen fibers are to each other (defined by the sum of all collagen pixel intensities divided by the unsaturated collagen area), where unsaturated collagen area is the area of collagen minus the area of collagen that has saturated pixels (i.e., a value of 255).

 

Collagen fiber density per tissues

CFDT

Sum of all collagen pixel intensities divided by the tissue area

 

Collagen tissue proportion

CTP

CTP is the ratio of CAR and TAR, which is equivalent to the ratio of collagen area by the tissue area. CTP = CART/100

Tissue intensity

Tissue area ratio

TAR

Relative amount of tissue compared to the total region of interest. The higher this number, the more tissue there is relative to the total region of interest

 

Tissue density

TD

Measure of how closely packed tissue fibers are to each other

Structure

Collagen reticulation index

CRI

A measure of how many collagen fiber branches there are within the entire length of the collagen network

 

Collagen area reticulation density

CARD

Ratio expression of the number of branch points relative to the area of collagen. The higher the ratio, the more branches there are per unit area within the area of collagen

 

Tissue reticulation index

TRI

A measure of how many tissue fragment branches there are within the entire length of the tissue network

 

Tissue area reticulation density

TARD

Ratio expression of the number of branch points relative to the area of the tissue. The higher the ratio, the more branches there are per unit area within the area of the tissue