Fig. 1: Representative myeloid neoplasms with t(3;12)(q26.2;p13).

a A representative case of BM core biopsy of AML with t(3;12)(q26.2;p13) (case #11) with a 100% hypercellular marrow with a cluster of dysplastic megakaryocytes, three of which are highlighted by arrowheads. b Aspirate shows myelodysplasia in erythroid precursors (top left: irregular nuclear contours; top right: irregular nuclear contours and cytoplasmic vacuolization; bottom left: nuclear cytoplasmic asynchrony) and megakaryocytes (bottom right: hypolobated). c Aspirate shows myelodysplasia in granulocytic precursors (top left: irregular nuclear contours and hypogranularity; top right: irregular nuclear contours; bottom left: pseudo-Pelger-Huet form) and megakaryocytes (bottom right: micro-megakaryocyte). d A representative case of BM core biopsy of therapy-related MDS with t(3;12)(q26.2;p13) (case #13) with a 30% cellular marrow. e Aspirate shows dysplasia in erythroid precursors with nuclear: cytoplasmic asynchrony and mildly irregular nuclear contours (arrowhead); dysplasia in granulocytic precursors with abnormal nuclear segmentation and abnormally clumped chromatin (arrows) as well as and pseudo-Pelger-Huet form granulocyte (inset). f Dysplastic megakaryocytes with separated nuclear lobes as well as the presence of a representative ring sideroblast (inset). g A representative BM core biopsy of CML-BP (CML, BCR-ABL1-positive, BP) with t(3;12)(q26.2;p13) (case #7) with a hypercellular marrow with extensive myelofibrosis. h Aspirate with increased blasts. i Reticulin stain demonstrates increased myelofibrosis, trichrome stain showed a few scattered collagen fibers (not shown) giving an overall grade of MF-2 (scale of MF-0–MF-3). Original magnification: a ×400; d, g, i ×200; e, f, h ×400; b, c, inset ×1000.