Table 4 Summary of Clinicopathologic Characteristics of Patients With t(3;12).

From: Myeloid neoplasms associated with t(3;12)(q26.2;p13) are clinically aggressive, show myelodysplasia, and frequently harbor chromosome 7 abnormalities

 

Current Study

Previous Studies [11 - 39]

Overall

Case number (N)

20

58

78

Age: median; range (yrs)

55.8 (27.8 – 78.8)

47.5 (4.8 - 87)

48.5 (4.8 – 87)

Myeloid Neoplasms with t(3;12): N (%)

 Acute Leukemia

  AML

11 (55%)

42 (72%)

53 (68%)

  MPAL

1 (5%)

0

1 (1%)

  MDS

2 (10%)

6 (10%)

8 (10%)

  MDS-EB

3 (15%)

2 (3%)

5 (6%)

MDS/MPN

 MDS/MPN-RS-T

0

1 (2%)

1 (1%)

 CML, BCR-ABL1-positive

2 (10%)

6 (10%)

8 (10%)

 aCML, BCR-ABL1-negative

0

1 (2%)

1 (1%)

PMF

1 (5%)

0

1 (1%)

Myeloid Neoplasms with t(3;12) as the only CG abnormality: N (%)

7

29

36

AML

2 (29%)

22 (76%)

24 (67%)

MDS

1 (14%)

4 (14%)

5 (14%)

MDS-EB

3 (43%)

2 (7%)

5 (14%)

MDS/MPN

 MDS/MPN-RS-T

0

1 (3%)

1 (3%)

MPN

 PMF

1 (14%)

0

1 (3%)

  1. (N) number, Age age at initial diagnosis, yrs years, t(3;12) the initial diagnosis of t(3;12)(q26.2;p13), AML acute myeloid leukemia, MDS-EB myelodysplastic syndrome with excess blasts, MDS myelodysplastic syndrome, MDS/MPN-RS-T myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis, CML chronic myeloid leukemia, aCML atypical chronic myeloid leukemia, PMF primary myelofibrosis, MPAL mixed-phenotype acute leukemia T/myeloid not otherwise specified.
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