Fig. 2: Methylation status of imprinting control regions (ICRs) of imprinted genes/gene clusters in mature ovarian teratomas, struma ovarii, complete hydatidiform mole, and extragonadal mature teratomas of females. | Modern Pathology

Fig. 2: Methylation status of imprinting control regions (ICRs) of imprinted genes/gene clusters in mature ovarian teratomas, struma ovarii, complete hydatidiform mole, and extragonadal mature teratomas of females.

From: Methylation profiles of imprinted genes are distinct between mature ovarian teratoma, complete hydatidiform mole, and extragonadal mature teratoma

Fig. 2

Numbers indicate cases in order of age. The color gradient from blue–white–red represents low to high percentages (0–50–100%) of the average methylation level. In mature teratomas and struma ovarii, the methylation levels of ICRs of maternally and paternally imprinted genes were high and low, respectively, although one struma ovarii resembling follicular adenoma (case 2) showed aberrant methylation levels in some ICRs. In CHMs, the overall methylation pattern was opposite to that observed in mature ovarian teratomas and struma ovarii. However, some ICRs of MEG3, H19, and NESPAS showed aberrant methylation levels. Extragonadal mature teratomas showed somatic or irregular methylation patterns (case 1, sacrococcygeal teratoma; cases 2–7, mediastinal teratomas).

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