Table 2 Interobserver variability based on grade, individual grading components, and histopathologic type.

From: Histologic grading of breast carcinoma: a multi-institution study of interobserver variation using virtual microscopy

 

Fleiss’ κa

Histologic grade

 

 1

0.705

 2

0.375

 3

0.491

Individual grade components

 

 Tubule formation

0.503

 Nuclear pleomorphism

0.403

 Mitotic rate

0.281

Tubule formation

 

 1

0.613

 2

0.300

 3

0.613

Nuclear pleomorphism

 

 1

0.158

 2

0.372

 3

0.467

Mitotic rate

 

 1

0.329

 2

0.121

 3

0.456

Histopathologic types

 

 IDC-NST

0.490

 ILC

0.092

 Other

0.606

  1. IDC invasive ductal carcinoma-no special type, ILC invasive lobular carcinoma.
  2. aFleiss’ κ scores denote levels of agreement: ≤0.20 = slight, 0.21–0.40 = fair, 0.41–0.60 = moderate, 0.61–0.80 = good, and 0.8–1.00 = very good.
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