Table 1 Clinicopathological and molecular results of TFEB rearranged renal cell carcinoma.

From: TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1

Case

Gender

Age

Size/laterality

Follow up

TFEB FISH

Partner gene

“Rosettes”

1

M

55

3 cm/R

NED 78 months

break 65%

NEAT1

no (3 slides)

2

F

81

6.5 cm/R

NED 12 months

break 91%

ACTB

no (6 slides)

3

F

54

7 cm/R

NED 36 months

break 80%

MALAT1

present in 2 of 8 slides

4

F

20

9.5 cm/R

NED 36 months

break 75%

MALAT1

present in 7 of 19 slides

5

F

40

14 cm/L

AWD 24 months

break 85%

MALAT1

present in 5 of 6 slides

6

M

69

10 cm/R

NED 6 months

break 70%

MALAT1

present in 19 of 35 slides

7

F

64

11 cm/L

NED 13 months

break 58%

MALAT1

present in 28 of 36 slides

8

F

19

5.5 cm/L

NED 2 months

break 74%

MALAT1

no (41 slides)

9

M

34

7 cm/L

NED 30 months

break 78%

MALAT1

no (42 slides)

10

F

42

10 cm/L

DOD 46 months

break 94%

MALAT1

no (17 slides)

11

M

33

8 cm/L

AWD 48 months

break 61%

MALAT1

no (7 slides)

12

M

73

16 cm/R

NED 1 month

break 80%

MALAT1

no (4 slides)

13

M

69

7 cm/L

AWD 14 months

break 80%

not found

no (1 slide)

  1. M male, F female, R right, L left, NED not evidence of disease, AWD alive with disease, DOD dead of disease.