Table 3 Mutation frequencies in 68 GCAs (this study) compared to UEAs, PAs, and IGAsa.

From: Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations

Gene

GCA (n = 68)

UEA (n = 21)

PA (n = 178)

IGA (n = 148)

TP53

41%

5%**

56%*

57%*

CDKN2A

18%

0%*

19%

1%**

KRAS

18%

11%

62%**

6%*

STK11

10%

0%

2%**

1%**

ERBB3

10%

14%

1%**

5%

GNAS

9%

5%

5%

3%

ERBB2

9%

18%

1%**

3%

SMAD4

9%

0%

19%*

7%

PIK3CA

7%

25%*

3%

11%

ARID1A

6%

10%

5%

14%

  1. GCA gastric-type cervical adenocarcinoma, UEA usual-type (HPV-associated) endocervical adenocarcinoma, PA pancreatic adenocarcinoma, IGA intestinal/tubular gastric adenocarcinoma.
  2. *p < 0.05, **p < 0.01, Fisher’s exact test (two-tailed, comparing mutation frequencies in GCA with those in each of the other cancer types).
  3. aMutation data for UEAs, PAs and IGAs from The Cancer Genome Atlas (TCGA) were retrieved from cBioPortal [36, 37].
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