Fig. 2: NTRK3 mRNA upregulation in BCOR family tumors.
From: NTRK3 overexpression in undifferentiated sarcomas with YWHAE and BCOR genetic alterations
Using whole transcriptome sequencing (a) and targeted RNA sequencing (b), upregulated NTRK3 expression was observed in round cell sarcomas with BCOR ITD, YWHAE rearrangements, BCOR-CCNB3, KMT2D-BCOR, and BCOR-CHD9 fusions, compared with other sarcomas on each platform (expression levels in RPKM). The NTRK3 levels observed in targeted RNA sequencing were higher than an infantile fibrosarcoma with EML4-NTRK3 fusion reference (b). An ossifying fibromyxoid tumor with ZC3H7B-BCOR fusion (a) and a synovial sarcoma (b) also had relatively increased NTRK3 expressions. No significant increase of NTRK3 expression level was observed in the single case of round cell sarcoma with BCOR-MAML3 fusion, an Ewing sarcoma with EWSR1-ERG fusion, nine CIC-DUX4 sarcomas (a), and solitary fibrous tumors (b).
