Fig. 3: Genetic heterogeneity of BCOR gene fusions in soft tissue round cell sarcomas. | Modern Pathology

Fig. 3: Genetic heterogeneity of BCOR gene fusions in soft tissue round cell sarcomas.

From: NTRK3 overexpression in undifferentiated sarcomas with YWHAE and BCOR genetic alterations

Fig. 3

BCOR-CCNB3 and BCOR-MAML3 fusions involve the 3′ end of BCOR encoding the PUFD domain of BCOR protein (a, b). Other less-common BCOR gene fusions showed variable breakpoints (c–f). Reciprocal fusion transcripts were identified in KMT2D-BCOR (d, recent case; e, previously reported case), and BCOR-CHD9 (f) fusions.

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