Fig. 4: Alternative BCOR fusions overexpressing pan-Trk.
From: NTRK3 overexpression in undifferentiated sarcomas with YWHAE and BCOR genetic alterations
Kidney tumor with the novel BCOR-CHD9 fusion in an adult female patient (a–e) showing primitive round to short spindle cell morphology (a) and strong pan-Trk staining (c), whereas being negative for BCOR (b) and NTRK1 (d). Loss of H3K27me3 expression was identified (e). Two cases with KMT2D-BCOR fusion showed a monotonous round to spindle morphology (f–j, pelvic tumor of a 10-year-old female; k–o, scapular tumor of a 38-year-old male patient), positive immunostaining for BCOR (g, l), pan-Trk (h, m), and TLE1 (j, n). NTRK1 staining was negative (i). Loss of H3K27me3 expression was also identified (o).
