Fig. 1: PD-L1 and PD-1 expression in small bowel adenocarcinomas (SBAs). | Modern Pathology

Fig. 1: PD-L1 and PD-1 expression in small bowel adenocarcinomas (SBAs).

From: PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability

Fig. 1: PD-L1 and PD-1 expression in small bowel adenocarcinomas (SBAs).The alternative text for this image may have been generated using AI.

A glandular celiac disease-associated SBA showing a strong and diffuse PD-L1 membranous staining on both tumoral and immune cells a (PD-L1 staining; original magnification × 200) and a high number of PD-1+ intratumoral lymphocytes b (PD-1 staining; original magnification × 400). c An EBV+ lymphoepithelioma-like Crohn’s disease-associated SBA with a diffuse PD-L1 membranous expression by tumor cells (PD-L1 staining; original magnification × 200). d A glandular Crohn’s disease-associated SBA with a low intratumoral infiltration of PD-1+ cells. (PD-1 staining; original magnification × 400). e A glandular sporadic SBA showing a faint membranous and cytoplasmatic PD-L1 staining on immune cells, localized either in the tumoral stroma or in the lumen of neoplastic glands. (PD-L1 staining; original magnification × 200 ). f The same sporadic case exhibiting a low number of intratumoral PD-1+ lymphocytes (PD-1 staining; original magnification × 400).

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