Table 3 Distribution of SBAs according to Teng type classification (in four tumor microenvironment immune types), MSI status, and etiologic group.

From: PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability

 

Teng type classification

p value

Type I

(PD-L1+/high TIL density)

Type II

(PD-L1−/low TIL density)

Type III

(PD-L1+/low TIL density)

Type IV

(PD-L1−/high TIL density)

Total, N (%)

24 (20)

62 (51)

7 (6)

28 (23)

 

MSI status, N (%)

Non-MSI

MSI-H

12 (15)

12 (31)

57 (69)

5 (13)

3 (4)

4 (10)

10 (12)

18 (46)

< 0.001

Etiologic group, N (%)

CeD-SBA

CrD-SBA

Sporadic SBA

11 (32)

11 (23)

2 (5)

9 (27)

27 (55)

26 (69)

1 (3)

6 (12)

0 (0)

13 (38)

5 (10)

10 (26)

< 0.001

  1. CeD-SBA celiac disease-associated small bowel adenocarcinoma, CrD-SBA Crohn’s disease-associated small bowel adenocarcinoma, MSI microsatellite instability, MSI-H microsatellite instability-high, PD-L1 programmed cell death ligand 1, SBA small bowel adenocarcinoma, TIL tumor-infiltrating lymphocyte.
  2. For Teng type classification, PD-L1 expression was evaluated with the combined positive score.
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