Fig. 2: Mutual exclusivity analysis, fraction of the genome altered and genetic alterations affecting the cell cycle pathway in primary and recurrent adult-type granulosa cell tumors of the ovary.

a Mutual exclusivity analysis between TERT promoter hotspot mutations and TP53 mutations in adult-type granulosa cell tumor (aGCT) recurrences. The type of mutations is color-coded according to the legend. Mutual exclusivity analysis was performed using combinations of mutually exclusive alterations (CoMET) and Fisher’s exact test. b Fraction of the genome altered in primary non-recurrent aGCTs, primary recurrent aGCTs, and aGCT recurrences. c Frequency of loss-of-function somatic genetic alterations affecting genes in the canonical cell cycle pathway. Genes are depicted in blue rectangles, and the percentage of primary non-recurrent aGCTs (Prim), primary recurrent aGCTs (Prim Rec), and aGCT recurrences (Rec) altered is shown below each gene.