Table 1 Clinical features.

From: High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities

Case

Age, years

Primary site

Stagea

Treatment prior to transformation

Time to transformation

Overall survival from transformation

1

53

Uterus

IIB

Surgery, hormonal therapy, chemotherapy

4 years

DOD, 2 years

2

55

Uterus

IIB

Surgery

0

NED, 2 years

3

53

Uterus

IVB

Surgery

0

DOD, 8 months

4

61

Vagina

I

Surgery

0

AWD, 12 months

5

45

Uterus

NA

Surgery

0

AWD, 2 years

6

51

Uterus

IIIA

Surgery

0

AWD, 20 months

7

74

Uterus

IB

Surgery

0

DOD, 2 years

8

50

Uterus

IIA

Surgery

10 years

AWD, 12 months

9

57

Uterus

IB

Surgery

11 years

NED, 8 years

10

69

Uterus

IVB

Surgery

0

DOD, 14 months

11

49

Uterus

IIA

Surgery

7 years

DOD, 18 months

12

71

Uterus

IB

Surgery

0

NED, 6 years

  1. AWD alive with disease, DOD died of disease, NA not available, NED no evidence of disease.
  2. aFIGO staging for uterine sarcomas was used for cases 1–3, 6–12; FIGO staging for vaginal cancer was used for case 4.
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