Fig. 3: Patterns of RAF1 and pERK immunostaining in acinar cell carcinomas.
From: RAF1 rearrangements are common in pancreatic acinar cell carcinomas
RAF1 expression in case 9 was enhanced at the tumor-stroma interface (a, main image) and in acini (a, inset), and at the tumor-stroma interface of case 12 (c). There was only weak diffuse cytoplasmic RAF1 staining in tumor cells in cases 17 (e) and 29 (g) that was less intense than in endothelial cells. pERK expression was intense at the tumor-stroma interface in case 9 (b, main image and inset), focally at the tumor-stroma interface in case 17 (f), and throughout the tumor in cases 12 (d) and 29 (h). Scale bar 200 µm in main images a, b, 100 µm in e, f, 50 µm in insets a, b and in c, d, g, h.
