Table 2 Morphological, clinical, genomic and immunohistochemical characteristics.
From: Molecular and clinicopathologic characterization of intravenous leiomyomatosis
Case | Morphology IVL | Morphology UL | Aggressive features | Alt | Chr | GI | p16 | Cyclin D1 | |
|---|---|---|---|---|---|---|---|---|---|
Group 1 | 1 | Cellular, epithelioid | N/A | Yes (EUE) | 7 | 5 | 9.8 | 2 | 4 |
2 | Cellular, focal hydropic, minimal hyalinization | N/A | No | 7 | 6 | 8.2 | 1 | 1 | |
3 | Cellular, focal vascular (capillary), focal hydropic, focal hyalinization, minimal hyalinized vessels | NAR | Yes (EUE, R) | 8 | 6 | 10.6 | 2 | 1 | |
4 | Cellular, vascular (capillary), focal hyalinization, focal hydropic, focal myopericytoma-like hyalinized vessels with minimal thrombi and hemosiderin | N/A | Yes (EUE, R) | 10 | 7 | 14.3 | 4 | 2 | |
5 | Usual | Usual | No | 17 | 15 | 19.3 | 1 | 2 | |
6 | Usual, hydropic, minimal hyalinization | NAR | Yes (EUE) | 14 | 11 | 17.8 | 3 | 1 | |
7 | Usual | Usual | No | 5 | 4 | 6.3 | 2 | 2 | |
8 | Usual, hyalinization, focal hydropic, focal hyalinized vessels | Usual | No | 4 | 4 | 4 | 2 | 1 | |
Group 2 | 9 | Cellular, hyalinization, focal hydropic, focal hyalinized vessels | Cellular, hyalinization, focal hydropic | No | 3 | 3 | 3 | 2 | 3 |
10 | Usual, focal hydropic, minimal hyalinization | N/A | Yes (EUE) | 3 | 3 | 3 | 2 | 2 | |
11 | Highly cellular | Highly cellular | No | 8 | 6 | 10.6 | 3 | 1 | |
12 | Usual, hydropic, hyalinization, focal hyalinized vessels | N/A | No | 1 | 1 | 1 | 4 | 4 | |
13 | Cellular, minimal hyalinization | N/A | Yes (EUE, R) | 5 | 5 | 5 | 1 | 1 | |
Group 3 | 14 | Highly cellular, minimal hyaline plaques, minimal adipose tissue, focal hyalinized vessels | Highly cellular | Yes (EUE) | 10 | 8 | 12.5 | 3 | 4 |
15 | Highly cellular, large vessels with thrombosis, myxoid change, extensive hemorrhage and hemosiderin | Usual, hyalinized | Yes (EUE) | 4 | 3 | 5.3 | 2 | 1 | |
16 | Cellular, hyaline plaques, minimal hydropic, minimal hyalinized vessels | Cellular, hyaline plaques, minimal hydropic | Yes (EUE) | 2 | 2 | 2 | 2 | 1 | |
17 | Cellular, vascular (arteriole-like), minimal hyaline plaques, hydropic, focal hyalinization, hyalinized vessels, hemosiderin | N/A | Yes (EUE, R) | 1 | 1 | 1 | 4 | 1 | |
18 | Cellular, hyaline plaques, adipose tissue, hemosiderin | N/A | No | 2 | 2 | 2 | 1 | 1 | |
Nonspecific | 19 | Usual, minimal hyalinization, minimal hyalinized vessels | Usual | No | 4 | 2 | 8 | 3 | 2 |
20 | Highly cellular (palisading schwannian morphology), focal hyaline plaques, minimal hyalinization | Highly cellular, focal hyaline plaques | Yes (EUE) | 6 | 3 | 12 | 1 | 1 | |
21 | Cellular, minimal hyalinization, minimal hydropic change, focal myxoid small to medium sized and minimal hyalinized vessels | Cellular leiomyoma with hydropic change | Yes (EUE) | 3 | 2 | 4.5 | 1 | 1 | |
22 | Usual, minimal hyaline plaques, hydropic, focal hyalinization, focal hyalinized vessels | Usual, hydropic, focal hyalinized | No | 5 | 4 | 6.3 | 1 | 1 | |
None | 23 | Usual, hyalinization, minimal hydropic, hyalinized vessels | N/A | No | 0 | 0 | 0 | 1 | 1 |
24 | Vascular (arteriole-like), minimal hyaline plaques, hyalinization, hyalinized vessels | N/A | Yes (EUE, R) | 0 | 0 | 0 | 3 | 1 | |
25 | Epithelioid, cellular | Epithelioid, cellular | No | 0 | 0 | 0 | 1 | 4 | |
26 | Usual, minimal hydropic | Usual, hyalinized | No | 0 | 0 | 0 | 1 | 1 | |
27 | Usual, hyalinized, minimal hydropic, hyalinized vessels | Usual | No | 0 | 0 | 0 | 4 | 4 | |
28 | Vascular (arteriole-like), focal hydropic change, minimal hyalinization | NAR | Yes (EUE) | 0 | 0 | 0 | 4 | 1 |
