Table 1 Clinicopathological characteristics according to DCIS-associated stromal changes.
From: Immune response and stromal changes in ductal carcinoma in situ of the breast are subtype dependent
Periductal stromal changes (n = 472) | Univariate P-value | Multivariate P-value | ||
|---|---|---|---|---|
Present (n = 143) n (%) | Absent (n = 329) n (%) | |||
Age at diagnosis (years) | 0.175 | – | ||
Median (range) | 58.0 (32.0–84.0) | 57.0 (27.0–84.0) | ||
Size (missing n = 65; cm) | <0.0001 | 0.054 | ||
Median (range) | 2.90 (0.30–13.50) | 1.70 (0.05–17.0) | ||
Growth pattern | 0.282 | – | ||
Solid | 81 (57) | 157 (48) | ||
Cribriform | 52 (36) | 138 (42) | ||
Micropapillary | 9 (6) | 28 (9) | ||
Papillary | 1 (1) | 6 (2) | ||
Grade | <0.0001 | 0.066 | ||
Low | 3 (2) | 60 (18) | ||
Intermediate | 27 (19) | 138 (42) | ||
High | 113 (79) | 131 (40) | ||
Calcification | 0.98 | – | ||
Absent | 34 (34) | 99 (30) | ||
Present | 109 (76) | 230 (70) | ||
Comedonecrosis | <0.0001 | <0.0001 | ||
Absent | 38 (27) | 195 (59) | ||
Present | 105 (73) | 134 (41) | ||
IHC DCIS subtype (missing n = 19) | <0.0001 | <0.0001 | ||
ER+PR±HER2− | 36 (25) | 223 (68) | ||
ER+PR±HER2+ | 30 (21) | 55 (17) | ||
ER−PR−HER2+ | 55 (38) | 30 (9) | ||
ER−PR−HER2− | 15 (10) | 9 (3) | ||
Density of TILs | <0.0001 | 0.011 | ||
Low | 70 (49) | 271 (82) | ||
High | 73 (51) | 58 (18) | ||
Ipsilateral recurence (missing n = 6) | 0.162 | – | ||
No | 131 (92) | 319 (97) | ||
Yes | 7 (5) | 9 (3) | ||
