Table 2 The association between DCIS regression and clinicopathological characteristics.
From: Immune response and stromal changes in ductal carcinoma in situ of the breast are subtype dependent
DCIS regression (n = 450) | Univariate P-value | Multivariate P-value | ||
|---|---|---|---|---|
Yes (n = 30) n (%) | No (n = 420) n (%) | |||
Age at diagnosis (years) | 0.469 | – | ||
Median (range) | 60.5 (32.0–81.0) | 58.0 (27.0–84.0) | ||
Size (missing n = 61; cm) | 0.001 | 0.069 | ||
Median (range) | 2.9 (2.80–3.00) | 2.0 (0.10–13.5) | ||
Growth pattern | 0.292 | – | ||
Solid | 20 (67) | 206 (49) | ||
Cribriform | 8 (27) | 176 (42) | ||
Micropapillary | 2 (7) | 33 (8) | ||
Papillary | 0 (0) | 5 (1) | ||
Grade | <0.0001 | 0.133 | ||
Low | 0 (0) | 58 (14) | ||
Intermediate | 4 (13) | 152 (36) | ||
High | 26 (87) | 210 (50) | ||
Calcification | 0.835 | – | ||
Absent | 9 (30) | 118 (28) | ||
Present | 21 (70) | 302 (72) | ||
Comedonecrosis | 0.013 | – | ||
Absent | 8 (27) | 215 (51) | ||
Present | 22 (73) | 205 (49) | ||
IHC DCIS subtype (missing n = 18) | <0.0001 | 0.002 | ||
ER+PR±HER2− | 5 (17) | 241 (60) | ||
ER+PR±HER2+ | 6 (20) | 75 (18) | ||
ER−PR−HER2+ | 13 (43) | 70 (17) | ||
ER−PR−HER2− | 6 (20) | 16 (4) | ||
Density of TILs | 0.006 | – | ||
Low | 15 (50) | 313 (75) | ||
High | 15 (50) | 107 (25) | ||
Ipsilateral recurence (missing n = 6) | 1.000 | – | ||
No | 28 (97) | 400 (96) | ||
Yes | 1 (3) | 15 (4) | ||
