Table 1 Clinical characteristics of patients with acral and non-acral melanoma.

From: TERT amplification but not activation of canonical Wnt/β-catenin pathway is involved in acral lentiginous melanoma progression to metastasis

Clinical characteristics

Primary acral melanoma (n = 34), no. (%)

Metastatic acral melanoma (n = 20), no. (%)

Primary non-acral melanoma (n = 10), no. (%)

Age, median, y

71

71

70

Sex

  Male

20

11

6

  Female

14

9

4

  Male: female ratio

1.4:1

1.2:1

1.5:1

Location of primary tumor

  Foot/toe

27 (79.3)

17 (85)

0

  Hand/fingers

5 (14.7)

0

0

  Ankle

1 (3)

1 (5)

0

  Nailbed, unspecified

1 (3)

2 (10)

0

  Arm

N/A

N/A

3 (30)

  Scalp

N/A

N/A

1 (10)

  Ear lobe

N/A

N/A

1 (10)

  Chest wall

N/A

N/A

1 (10)

  Cheek

N/A

N/A

2 (20)

  Back

N/A

N/A

2 (20)

Stage

  I

2 (5.8)

0

2 (20)

  II

11 (32.4)

0

3 (30)

  III

8 (23.6)

0

1 (10)

  IV

13 (38.2)

20 (100)

4 (40)

Median survival (months)

50 months

95 months

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