Table 4 Gene mutation status of BRAF, KIT, and NRAS in acral and non-acral melanoma and acral nevi.

From: TERT amplification but not activation of canonical Wnt/β-catenin pathway is involved in acral lentiginous melanoma progression to metastasis

Gene mutations

Primary acral melanomas (n = 34), no. (%)

Metastatic acral melanomas (n = 20), no. (%)

Primary non-acral melanomas (n = 10), no. (%)

Acral nevi (n = 15), no. (%)

BRAF V600E*

7 (20.5)

2 (10)

3 (30)

10 (66.7)

KIT

3 (8.8)

2 (10)

0

0

NRAS

1 (2.9)

4 (20)

0

0

  1. *By immunohistochemistry or gene sequencing.
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