Fig. 2: ALK-RCC demonstrated heterogeneous morphology (case #1). | Modern Pathology

Fig. 2: ALK-RCC demonstrated heterogeneous morphology (case #1).

From: ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217

Fig. 2

a Lower power magnification showed admixed solid (center), papillary and trabecular (right), and sarcomatoid (spindle cell) areas (lower-left) (×100). b Exuberant papillary formations and abundant psammoma bodies were present focally, resembling papillary RCC, type 1; note the mucinous background (×200). c Other areas showed small tubules and glands with low-grade nuclei, set in a fibrous stroma (×200). d There were focal sarcomatoid (spindle cell) areas, with scattered individual epithelioid cells (×200). e Foci of atypical rhabdoid and signet-ring cells were also present (×600). f ALK immunostaining highlighted the infiltrating neoplastic cells, while the stromal and inflammatory cells were negative (×200).

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