Table 3 Microscopic findings in ALK-RCC.

From: ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217

Case No.

Necrosis

Cytoplasmic vacuoles

Rhabdoid morphology

Sarcomatoid (spindle) cells

Signet-ring cells

MA morphology

Psammoma bodies

Mucin (background)

Original Diagnosis

1

+

+

+

+

+

+

uRCC

2

+

MTSC-RCC

3

100%

MA

4

+

+

+

5%

+

+

ALK-RCC

5

+

+

+

+

+

uRCC

6

+

+

uRCC

7

+

+

+

+

+

ALK-RCC

8

+

+

uRCC

9

+

+

+

+

+

ALK-RCC

10

+

ALK-RCC

11

+

+

+

uRCC

12

+

MA-like

Percent pos*

33%

33%

50%

17%

42%

17%

50%

75%

 
  1. + present (positive), − absent (negative), uRCC unclassified RCC, MTSC-RCC mucinous tubular and spindle cell renal cell carcinoma, MA metanephric adenoma.
  2. *Percent positive includes both focal and diffuse positive cases.