Table 3 SARS-CoV-2 immunohistochemical findings and histologic correlates in seven patients with COVID-19 who underwent autopsy.
From: In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19
SARS-CoV-2 IHC on trachea | SARS-CoV-2 IHC on lung | |||||||
|---|---|---|---|---|---|---|---|---|
Case No. | Lung histology | Pulmonary thromboembolism | Extent of staining | Cell type staining positive | Histology corresponding to areas with positive staining | Extent of Staining | Cell type staining positive | Histology corresponding to areas with positive staining |
1 | Acute DAD (with scattered foci of organizing DAD) Interstitial lung disease with bronchiectasis | + | − | N/A | N/A | + | Pneumocytes | Acute DAD |
2 | Acute DAD (with scattered foci of organizing DAD) | + | − | N/A | N/A | + | Pneumocytes | Acute DAD |
3 | Acute DAD (with scattered foci of organizing DAD) Superimposed bacterial lobar pneumonia | + | − | N/A | N/A | + | Pneumocytes | Acute DAD |
4 | Acute DAD (with scattered foci of organizing DAD) Prominent reactive pneumocyte hyperplasia Superimposed bacterial lobar pneumonia Aspergillus abscess | − | + | Ciliated airways cells, rare epithelial cells in submucous glands | Focally denuded airway mucosa with focal squamous metaplasia | ++ | Pneumocytes | Acute DAD |
5 | Acute DAD Prominent reactive pneumocyte hyperplasia | + | ++ | Ciliated airways cells, epithelial cells in submucous glands | Focally denuded airway mucosa with focal squamous metaplasia | +++ | Pneumocytes, few macrophages | Acute DAD |
6 | Organizing lung injury/DAD | − | − | N/A | N/A | − | N/A | N/A |
7 | Organizing lung injury/DAD Superimposed bacterial lobar pneumonia | + | − | N/A | N/A | − | N/A | N/A |
